Comparison of post-operative pain in morphine-addicted and non-addicted rats

Authors: not saved
Abstract:

Post-operative pain and its management remains one of the most important issues in the field of surgery and health care system. On the other hand, opioid drug abuse has a large prevalence in Iran. Formalin test has been used as a method for assessing pain and analgesia in rats. In the present study, the post-operative pain in morphine addicted rats was compared with that of non-addicted ones using formalin test. For this purpose, 26 rats were chosen and randomly divided into two groups. First group received morphine sulphate in their drinking water for 21 days. The other group received only tap water. On the day of their assessment, a longitudinal incision (1-cm) was made through skin fascia of their plantar aspect of one foot under ether anesthesia. One hour later, their pain was assessed with formalin test through intra-plantar subcutaneous injection of 0.05 ml of 2.5% formalin solution. Our results showed that acute pain (the first 5 minutes after injection) in both groups was not different significantly, but chronic pain (the next 15-45 minutes) was much intense in morphine-addicted rats.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

comparison of post-operative pain in morphine-addicted and non-addicted rats

post-operative pain and its management remains one of the most important issues in the field of surgery and health care system. on the other hand, opioid drug abuse has a large prevalence in iran. formalin test has been used as a method for assessing pain and analgesia in rats. in the present study, the post-operative pain in morphine addicted rats was compared with that of non-addicted ones us...

full text

Comparison of satisfaction with post-operative pain management and level of functional interferance in addicted and non-addicted patients

Introduction: Postoperative pain relief in addicted patients compared with non-addicted patients is often more challenging and they usually suffer from inadequate postoperative pain relief. Objective: The purpose of this study was to compare satisfaction with postoperative pain management in addicted and non-addicted patients and level of pain interference with their functions. Methods: In th...

full text

Efficacy of Additives to Morphine Pumps in Post-Operative Pain Control of Addicted Patients

Acute pain management in opioid dependent patients remains a challenging and complex problem and it is becoming more common (1). In the acute pain setting, in addition to their daily opioid maintenance these patients need a multimodal approach (1). Imani et al. in their study have shown that instead of simply increasing the dosage of morphine, using morphine in addition to chlorpromazine, prome...

full text

Evaluation of wound healing and post-operative intra-abdominal adhesions in opium addicted rats

Introduction: Opium addiction can change immune response to Types of stress such as injury or trauma due to alterations in the in secretion status of cytokines in the body. In this study, effects of opium addiction on wound healing and post-operative adhesion bands were assessed after laparotomy. Materials and Methods: Male rats (n=20) were randomly divided into opium addicted (documented with ...

full text

A Comparison between APGAR Scores and Birth Weight in Infants of Addicted and Non-Addicted Mothers

Background: Addiction in pregnant women causes complications such as abortion, asphyxia and cerebral and physical problems. APGAR score assesses vital signs and birth weight and represents the physical and brain growth of newborns. In this study, the effects of opium addiction in mothers on birth weight and APGAR scores of neonates were discussed.Methods: This study analytic, descriptive study ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue None

pages  153- 160

publication date 2001-11

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023